“can we genetically improve intelligence?”

coupla popsci (*cough*eugenics*cough*) videos for ya from AsapSCIENCE and Vsauce3. h/t emil kirkegaard (no relation)!


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linkfest – 01/21/14

Calcium absorption not the cause of evolution of milk digestion in Europeans“‘The evolution of lactase persistence is one of the best known and most dramatic examples of recent human evolution. One of the ironies of working in this area is that we know it happened but we still don’t fully know why’ says Sverrisdóttir. Lactase persistence is found at highest frequencies in southern Sweden and in Ireland. Given that calcium absorption is not the only reason why this trait evolved so rapidly, Sverrisdóttir and colleagues have proposed another cause: Although most early European farmers would not have been lactase persistent, they would still have been able to consume fermented milk products such as yoghurt and cheese, because fermentation converts much of the lactose into fats. But in famine conditions, such as when crops fail, they are likely to have eaten all the fermented milk foods, leaving only the more high-lactose products. This would have caused the usual lactose intolerance symptoms such as diarrhea. Diarrhea in in healthy people is not usually life-threatening, but in severely malnourished individuals it certainly can be. So famine could have led to episodes of very strong natural selection favoring lactase persistence.”

Human and Helicobacter pylori coevolution shapes the risk of gastric disease“Patients were recruited from two geographically distinct Colombian populations with significantly different incidences of gastric cancer, but virtually identical prevalence of H. pylori infection. All H. pylori isolates contained the genetic signatures of multiple ancestries, with an ancestral African cluster predominating in a low-risk, coastal population and a European cluster in a high-risk, mountain population. The human ancestry of the biopsied individuals also varied with geography, with mostly African ancestry in the coastal region (58%), and mostly Amerindian ancestry in the mountain region (67%). The interaction between the host and pathogen ancestries completely accounted for the difference in the severity of gastric lesions in the two regions of Colombia. In particular, African H. pylori ancestry was relatively benign in humans of African ancestry but was deleterious in individuals with substantial Amerindian ancestry. Thus, coevolution likely modulated disease risk, and the disruption of coevolved human and H. pylori genomes can explain the high incidence of gastric disease in the mountain population.”

Seeing X Chromosomes in a New Light“X-chromosome inactivation, Dr. Nathans’s pictures show, creates a genetic diversity that’s particularly dramatic. Two cells side by side may be using different versions of many different genes. ‘But there is also much larger-scale diversity,’ Dr. Nathans said. In some brains, for example, a mother’s X chromosome was seen dominating the left side, while the father’s dominated the right. Entire organs can be skewed toward one parent. Dr. Nathans and his colleagues found that in some mice, one eye was dominated by the father and the other by the mother. The diversity even extended to the entire mouse. In some animals, almost all the X chromosomes from one parent were shut; in others, the opposite was true.”

Are plants altruistic?“Roots can distinguish self from other, and they know their own kind (species), they can share resources and information about insect attacks and deliver nutrients to trees in need. The preponderance of evidence does seem to suggest that plants are proactive in filling their own needs and the needs of others.” – ooooh, not just their own species, their own close relatives! – see also The Intelligent Plant.

Sluggish metabolisms are key to primates’ long lives“[P]rimates expend 50 per cent less energy than other mammals of equivalent mass during an average day. ‘What’s more, he says the difference is not easily explained by differing activity levels: a human would need to run a whole marathon every day to be on an even energetic footing with mammals that aren’t primates….’ The finding offers a completely new way to understand why primates have slower life histories than other mammals of equivalent body size…. Pontzer thinks that the slower metabolism may have evolved to help primates cope with food shortages. For instance, orang-utans suffer frequent famines. ‘Orang-utans experience extended periods of low fruit availability,’ says Vogel. ‘There are months when caloric intake is less than expenditure – and they burn body fat stores.’ A slow metabolism might help them survive.”

Triune origins“With the latest paper, the story on European origins is becoming clearer. Three populations account for European ancestry: the Mesolithic hunter-gatherers of western Europe (dubbed WHG in the paper), early European farmers derived from somewhere in the Mideast (EEF), and a third group more closely related to ancient Siberians (ANE) than any existing population. Those Sibermen also contributed a third of Amerindian ancestry, the rest being similar to modern East Asian populations.” – from greg cochran.

The first industrial revolution“As early modern humans spread farther north, they entered more challenging environments…. Did these new cognitive demands have an evolutionary impact? Did they select for certain mental capacities over others? Piffer (2013) has addressed these questions by seeing how hunter-gatherers differ from farming peoples in alleles at COMT, a gene linked to executive function, working memory, and intelligence…. Northern hunting peoples, however, differ from other hunter-gatherers and resemble more advanced farming populations.” – from peter frost.

‘Out of Africa’ gene mutation in human pigmentation increases predisposition to skin cancer“The V60L mutation is more common in people with light hair and skin tone that, despite being light, tans easily in the summer. This mutation is positive for the climate of the Mediterranean region, as it facilitates the absorption of vitamin D in the winter months, in which the ultraviolet radiation is lower. In the summer months, in which the radiation is greater, the ease to darken the skin pigmentation provides a certain protection. However, the study also revealed that among people with this mutation there is a greater predisposition to skin cancer.” – see also: Simultaneous Purifying Selection on the Ancestral MC1R Allele and Positive Selection on the Melanoma-Risk Allele V60L in South Europeans.

Longitudinal four-dimensional mapping of subcortical anatomy in human development – h/t kevin mitchell! who said: “Large imaging study details substantial sex differences in maturation dynamics of subcortical structures.” – also: Fundamental sex difference in human brain architecture [behind paywall].

Changes in Thickness and Surface Area of the Human Cortex and Their Relationship with Intelligence“At 10 years of age, more intelligent children have a slightly thinner cortex than children with a lower IQ. This relationship becomes more pronounced with increasing age: with higher IQ, a faster thinning of the cortex is found over time. In the more intelligent young adults, this relationship reverses so that by the age of 42 a thicker cortex is associated with higher intelligence. In contrast, cortical surface is larger in more intelligent children at the age of 10. The cortical surface is still expanding, reaching its maximum area during adolescence. With higher IQ, cortical expansion is completed at a younger age; and once completed, surface area decreases at a higher rate. These findings suggest that intelligence may be more related to the magnitude and timing of changes in brain structure during development than to brain structure per se, and that the cortex is never completed but shows continuing intelligence-dependent development.”

Why do spatial abilities predict mathematical performance?“About a third of the variation in spatial ability at age 12 is explained by genetic factors; a little less than half of the variation in mathematics at this age is genetic. We find no sex differences in the genetic and environmental influences (either in magnitude or type) on mathematical and spatial variation at age 12. The observed overlap between spatial ability and mathematics is substantial (r > .40). Approximately 60% of this overlap is explained by common genetic effects, with 40% of the overlap due to environmental experience.” – h/t DOCTOR stuart ritchie! (^_^)

New evidence shows the FDA was wrong to halt 23andMe testing“While the tests are often too inaccurate for consumers to consider them diagnoses, research shows that most customers will seek a doctor’s opinion before taking action, anyway. According to the authors’ research, 58% of 1,051 surveyed customers did nothing at all with their genomic results. Of the 42% who made health decisions based on the information, only 2% changed prescription drug regimens without consulting a physician. The majority of customers who made changes focused on diet, exercise, and vitamins.”

Dogs’ Closest Wolf Ancestors Went Extinct, Study Suggests” A new genetic analysis of modern dogs and wolves suggests that man’s best friend was domesticated before agriculture. But the origin of this domestication remains stubbornly mysterious. Researchers analyzed the genomes of wolves from three likely sites of domestication (the Middle East, Asia and eastern Europe), and found that modern dogs were not more closely related to any of the three. In fact, it seems that the closest wolf ancestors of today’s dogs may have gone extinct, leaving no wild descendants.” – also: Paedomorphic Facial Expressions Give Dogs a Selective Advantage – woof! – h/t claire lehmann!

The Nurture Enigma – How Does the Environment Influence Human Nature? – from staffan.

The interplay of genetic and cultural evolution – from jason collins.

Eye of the Tiger PeopleBut what the hell is ‘culture,’ anyway? Talk about a social construct! Even the term ‘social construct’ is a social construct, one unique to our culture. And who’s to say culture is entirely separate from genetics? There’s some suggestion that the two may be intimately intertwined. In rawest terms, ‘culture’ may be nothing more than what happens when a group’s genes interact with their environment. – from jim goad.

Toddlers’ aggression is strongly associated with genetic factors, study reports“The development of physical aggression in toddlers is strongly associated genetic factors and to a lesser degree with the environment, according to a new study led by Eric Lacourse of the University of Montreal and its affiliated CHU Sainte-Justine Hospital. Lacourse’s worked with the parents of identical and non-identical twins to evaluate and compare their behaviour, environment and genetics.” – h/t mr. mangan, esq!

Modifying DNA May Wipe Away Old Memories – so can several double gin and tonics in a row. (~_^) – they’re talking about epigenetic changes here, btw.

Apes are intuitive statisticians“Here, we conducted the first investigation of such intuitive statistical reasoning with non-human primates. In a series of 7 experiments, Bonobos, Chimpanzees, Gorillas and Orangutans drew flexible statistical inferences from populations to samples. These inferences, furthermore, were truly based on statistical information regarding the relative frequency distributions in a population, and not on absolute frequencies. Intuitive statistics in its most basic form is thus an evolutionarily more ancient rather than a uniquely human capacity.” – iow, the other great apes outperform a lot of humans (i.e. the pc ones)! (~_^) – h/t neuroskeptic!

Study: Chimpanzees Bond Over Shared Meals“[C]himps who share their food have higher levels of oxytocin, known as the love hormone, than those who don’t.” – h/t hbd bibliography!

Comedians have psychotic personality traits, study finds“In a study in the British Journal of Psychiatry, researchers analyzed comedians from Australia, Britain and the United States and found they scored significantly higher on four types of psychotic characteristics compared to a control group of people who had non-creative jobs. The traits included a tendency towards impulsive or anti-social behavior, and a tendency to avoid intimacy. ‘The creative elements needed to produce humor are strikingly similar to those characterizing the cognitive style of people with psychosis – both schizophrenia and bipolar disorder,’ said Gordon Claridge of the University of Oxford’s department of experimental psychology, who led the study.”

Natural selection can favour ‘irrational’ behaviour – well, there’s your problem!

‘Human evolution likely led to rise of religion’ – h/t holly dunsworth! whose response was: duh! (~_^)

New study finds mistimed sleep disrupts rhythms of genes in humans“During this disruption of sleep timing, there was a six-fold reduction in the number of genes that displayed a circadian rhythm (a rhythm with an approximately 24 hour period). This included many regulators associated with transcription and translation, indicating widespread disruption to many biological processes.” – sleep right!

speaking of which: Study finds later school start times improve sleep and daytime functioning in adolescents – h/t anatoly!

The human brain can process images the eye sees for 13 milliseconds – imagine how quickly THE FLASH’s brain can process images!! (~_^)

The Islamic Republic of Baby-Making“Iran, like other Middle Eastern countries, has an extremely high infertility rate. More than 20 percent of Iranian couples cannot conceive, according to a study conducted by one of the country’s leading fertility clinics, compared with the global rate of between 8 and 12 percent. Experts believe this is due to the prevalence of consanguineous marriages, or those between cousins. Male infertility is ‘the hidden story of the Middle East,’ says Marcia Inhorn, a Yale University medical anthropologist and a specialist on assisted reproduction in the region.”

This Language Names Odors As Precisely As English Speakers Name Colorjahai speakers in malaysia. – h/t t.greer! – see also: Can You Name That Smell?“It’s also possible that the Jahai are built differently than the rest of us. The genes that code for the olfactory receptors in our noses exhibit a great deal of variation not only between different human populations but also between people. So it may be that the Jahai have evolved more of these receptors or a greater diversity of them than everyone else, much like the Tsimane tribe from the Bolivian rainforest were shown to be more sensitive to smells than were Germans.”

Gene therapy ‘could be used to treat blindness’“Surgeons in Oxford have used a gene therapy technique to improve the vision of six patients who would otherwise have gone blind. The operation involved inserting a gene into the eye, a treatment that revived light-detecting cells.”

The thinnest Americans are Asian Americans, CDC data show – surprise!

Shapely centrefolds? Temporal change in body measures: trend analysis – h/t ben southwood! who said: “Playboy centrefolds’ waists have widened, weights have fallen, busts have shrunk and hips have narrowed since 1953.”

Study: Violence, infectious disease and climate change contributed to Indus civilization collapse – h/t mike anissimov!

What was in that grog? Scientists analyze ancient Nordic drink“Ancient Scandinavians quaffed an alcoholic mixture of barley, honey, cranberries, herbs and even grape wine imported from Greece and Rome, new research finds.” – mmmmmm! mmmmmm?

bonus: i’m a journalist! – h/t jayman!

bonus bonus: and a neo-fascist, too, apparently. hahahahahahahaha!! *snort*

bonus bonus bonus: Genetically engineered plant glows so brightly it can be used as a LAMP

(note: comments do not require an email. memory erasers.)

linkfest – 11/19/13

Lyme bacteria show that evolvability is evolvable“Natural selection favours those with a greater capacity to generate genetic variation.”

50,000 generations of bacteria prove that evolution never stops“[C]omputer models have shown that animals can still experience significant evolutionary changes over time, even in the absence of selectional pressures. Traits like evolvability, or evolutionary potential. Indeed, the Lenski study shows that the same holds true when working with organisms in evolutionary ‘real time.’ The researchers, who performed a comparative analyses of the bacteria after every 500 generations, showed that E. coli will continue to evolve towards increasing replicative efficiency.” – h/t peter turchin! – see also Krazy Kats from greg cochran.

Mystery humans spiced up ancients’ rampant sex lives“Genome analysis suggests interbreeding between modern humans, Neanderthals, Denisovans and a mysterious archaic population.” – see also: Mystery human species emerges from Denisovan genome.

Out of Africa revisited (entrevista a Chris Stringer)“To what extent do these differences in evolutionary paths, if any, affect the human biodiversity we see today? That is still unclear, but will become clearer in the next few weeks with the publication of new data….”

Neanderthal virus DNA spotted hiding in modern humans“The DNA of ancient viruses first spotted in the Neanderthal genome have now been identified in modern humans…. [The researchers] examined the genomes of 67 people with cancer, and found they each contained seven of the sequences supposedly unique to the ancient humans.”

How Our Minds Went Viral“Based on this research, the scientists propose a scenario. Our ancestors millions of years ago were infected with a virus. Eventually it became lodged in our genome. At some point, a mutation moved the virus enhancer next to the PRODH gene. Further mutations allowed it to helped boost the gene’s activity in certain areas of the brain, such as the hippocampus…. Perhaps our minds are partly the way they are today thanks to an infection our ancestors got a few millions of years ago.” – h/t john durant!

Reconstructing the Population Genetic History of the Caribbean“‘We find evidence of two pulses of African migration. The first pulse—which today is reflected by shorter, older ancestry tracts—consists of a genetic component more similar to coastal West African regions involved in early stages of the trans-Atlantic slave trade. The second pulse—reflected by longer, younger tracts—is more similar to present-day West-Central African populations, supporting historical records of later transatlantic deportation. Surprisingly, we also identify a Latino-specific European component that has significantly diverged from its parental Iberian source populations, presumably as a result of small European founder population size. We demonstrate that the ancestral components in admixed genomes can be traced back to distinct sub-continental source populations with far greater resolution than previously thought, even when limited pre-Columbian Caribbean haplotypes have survived.'” – @dienekes’.

Correlations in the population structure of music, genes and language“‘[T]he first quantitative evidence that music and genes may have coevolved by demonstrating significant correlations between traditional group-level folk songs and mitochondrial DNA variation among nine indigenous populations of Taiwan.” – @dienekes’.

Wolves turned into dogs by European hunter-gatherers – h/t hbd bibliography!

The Paradox of Diverse Communities“Their simulations of more than 20 million virtual ‘neighborhoods’ demonstrate a troubling paradox: that community and diversity may be fundamentally incompatible goals…. After 20 million-plus simulations, the authors found that the same basic answer kept coming back: The more diverse or integrated a neighborhood is, the less socially cohesive it becomes, while the more homogenous or segregated it is, the more socially cohesive…. [T]he models demonstrated that it was impossible to simultaneously foster diversity and cohesion ‘in all reasonably likely worlds.’ In fact, the trends are so strong that no effective social policy could combat them, according to Neal. As he put it in a statement, ‘In essence, when it comes to neighborhood desegregation and social cohesion, you can’t have your cake and eat it too.'” – see also original research article: The (In)compatibility of Diversity and Sense of Community [pdf]. – h/t nearly everybody on twitter!

A Review of ‘The Diversity Illusion’ by Ed West – from peter hitchens. – The Diversity Illusion.

War’s Enduring Effects on the Development of Egalitarian Motivations and In-Group Biases“[G]reater exposure to war created a lasting increase in people’s egalitarian motivations toward their in-group, but not their out-groups, during a developmental window starting in middle childhood (around 7 years of age) and ending in early adulthood (around 20 years of age). Outside this window, war had no measurable impact on social motivations in young children and had only muted effects on the motivations of older adults.” – h/t t.greer!

It’s nothing to sniff at: Men have bigger noses because of more muscle“Men may have larger noses than women because they generally have more muscle, demanding larger noses to breathe in more oxygen….” – h/t mr. mangan, esq.!

Rural White Liberals – a Key to Understanding the Political Divide“there are likely several factors involved in shaping the modern American political landscape. Of which, the strongest may be ethnonational origin. This is buttressed by population density pressure, founder effects, internal self-sorting, and perhaps even recent evolution.” – from jayman.

John Horgan and the “Warfare is Innate” Red Herring“The Blank Slate may be dead, but its zombies still walk among us.” – (~_^) – from helian.

A Little Speculation About Disgust Sensitivity and Attitudes Towards Homosexuals and People of Other Races – ewwww! – from staffan

They aren’t meant to pee standing up – well, not without one of these, but frankly that’s gross. – the awesome epigone on how happy teh feminists are (not).

Open letter to Morten Kjeldgaard – (~_^) – from elijah. – see also Was the Scientific Dishonesty Minister trying to suppress population estimates? from dr. james thompson.

The White man has no friends“Over the past millennium, Western Europeans have created a social environment where the individual is largely free from collective ties of kinship and ethnicity. Because the State has imposed a monopoly on the use of violence, there is less need to rely on kinsmen to safeguard one’s life and property.” (and ’cause of The Outbreeding Project, too, imho. (^_^) ) – from peter frost.

Preclinical testing shows SUMO-1 gene therapy shrinks an enlarged heart, improves heart funcion, and blood flow, human trials to start – h/t mike anissimov!

Borjas, Grogger, and Hanson: Immigrant and Native Complementarity“George Borjas, Jeffrey Grogger, and Gordon Hanson have a new paper, and it’s not good news for the Ottaviano and Peri result that immigration can cause native wages to increase due to strong complementarities between native and immigrant labor.” – h/t heartiste!

Is Jared Diamond racist? – oh, noes! not a waaaaycist! (hmmmm. maybe he is….) – h/t peter turchin!

Stunning Portraits Of The World’s Remotest Tribes Before They Pass Away – h/t heartiste!

bonus: William Pollack Dies at 87; His Vaccine Saved Infants“William Pollack, a medical researcher who helped develop a vaccine that virtually eradicated a disease [Rh disease] once responsible for 10,000 infant deaths a year in the United States, died on Nov. 3 in Yorba Linda, Calif. He was 87.”malcom pollack‘s dad. =( see also: William Pollack, R.I.P. from mr. mangan, esq.

bonus bonus: working first chapter of A Part-time Job in the Country by luke lea! send comments to luke.

bonus bonus bonus: I’ve realised why I like the Dutch so much: they invented capitalism – from dan hannan. (just missing the biology! (~_^) ) – see also: The World of English Freedoms“It’s no accident that the English-speaking nations are the ones most devoted to law and individual rights, writes Daniel Hannan.”

bonus bonus bonus bonus: It’s time to confront this taboo: First cousin marriages in Muslim communities [in the u.k.] are putting hundreds of children at risk“Many NHS doctors, while admitting privately there is a crisis, refuse to speak out for fear of being branded ‘racist’.”

bonus bonus bonus bonus bonus: Thus Spake Obama“The incompetence of our neo-monarchy.” – from mark steyn. – h/t charles murray!

bonus bonus bonus bonus bonus bonus: Wine: Drinking in the Mother Vine“[R]eportedly the oldest cultivated grapevine in North America.”

bonus bonus bonus bonus bonus bonus bonus: Scientists date world’s oldest animal at 507 years old — after they accidentally kill it – *facepalm* – h/t nelson!

(note: comments do not require an email. ming – the ex-world’s oldest animal.)