Archives for posts with tag: crispr

a linkfest! =D

Experimental evolution reveals hidden diversity in evolutionary pathways“Our findings show that parallel genetic evolution is strongly biased by constraints and we reveal the genetic bases. From such knowledge, and in instances where new phenotypes arise via gene activation, we suggest a set of principles: evolution proceeds firstly via pathways subject to negative regulation, then via promoter mutations and gene fusions, and finally via activation by intragenic gain-of-function mutations. These principles inform evolutionary forecasting and have relevance to interpreting the diverse array of mutations associated with clinically identical instances of disease in humans.”

Selectionism Strikes Back! – from razib.

Genomes carry a heavy burden“Most people’s DNA contains genetic mutations that are potentially lethal to offspring…. Most people carry one or two genetic mutations that can cause early death or infertility in their offspring….”

World’s oldest stone tools discovered in Kenya“Researchers…say they have found the oldest tools made by human ancestors — stone flakes dated to 3.3 million years ago. That’s 700,000 years older than the oldest-known tools to date, suggesting that our ancestors were crafting tools several hundred thousand years before our genus Homo arrived on the scene. If correct, the new evidence could confirm disputed claims for very early tool use, and it suggests that ancient australopithecines like the famed ‘Lucy’ may have fashioned stone tools, too.”

Neanderthals manipulated the bodies of adults and children shortly after death

Neandertal flutes debunked – @dienekes’.

IQ prediction from structural MRI – from steve hsu. see also: MRI-Based Intelligence Quotient (IQ) Estimation with Sparse Learning.

New brain science shows poor kids have smaller brains than affluent kids – see also: Credit, where credit is due, to Lyndsey Layton and Income, brain, race: Prof Kimberly Noble replies and Howitzer or Katyusha: Reply to Prof Noble at dr. james thompson’s blog. – and see also: In today’s social science, wishing makes it so – from charles murray.

Gene study may explain why some remain quick thinkers“Genetic differences could explain why some people are quicker thinkers in middle age and later life, a study of data from 30,000 people suggests.” – see also: GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

Prediction of brain age suggests accelerated atrophy after traumatic brain injury – h/t stuart ritchie! who tweeted: “Super-cool new paper on how to predict someone’s age just from a brain image (r = .92!)”

National Wealth and IQ at the Edge: American Exceptionalism, East Asian Mediocrity – anatoly karlin’s “big-ass blog on national wealth, IQ, HBD, East Asians, smart fractions, etc.” (~_^)

In the beginning was the Word – dr. james thompson blogs on the recent woodley et al. paper “By their words ye shall know them: Evidence of genetic selection against general intelligence and concurrent environmental enrichment in vocabulary usage since the mid 19th century.”

Born That Way – from greg cochran.

Female Same-Sex Attraction Revisited – from jayman.

Examining the S factor in Mexican states – from emil kirkegaard.

Sex differences and vulnerability: how the male-female divide affects health“[S]ome studies have shown that premature baby girls will grow up to suffer greater language deficits than premature boys, whereas boys exposed to certain prenatal toxins will suffer greater deficits to spatial skills than girls similarly exposed, but because sex differences were never the original focus of the research no one, until Geary, has united these sex specific developmental problems and placed them in evolution’s bigger picture. Geary explains, ‘Sexually selected traits are the first to go; for example, low level exposure to prenatal toxins will affect play in boys but not their IQ: if you don’t measure the right thing you will fail to detect underlying problems.'” – h/t steve stewart williams!

Men up to five times more likely to commit sex crimes than the average male if they have brother or father convicted of a sex offence – h/t claire lehmann! who tweeted: “Survey of 21,566 men convicted of sex crimes from 1973- 2009 has revealed a strong genetic component to sex offending.” – see also: Sexual offending runs in families: A 37-year nationwide study.

Aggressive-Antisocial Boys Develop Into Physically Strong Young Men“We found that males’ antisocial tendencies temporally precede their physical formidability. Boys, but not girls, with greater antisocial tendencies in childhood attained larger increases in physical strength between the ages of 11 and 17. These results support sexual selection theory, indicating an adaptive congruence between male-typical behavioral dispositions and subsequent physical masculinization during puberty.”

Childhood Self-Control and Unemployment Throughout the Life Span: Evidence From Two British Cohort Studies“Analyzing unemployment data from two nationally representative British cohorts (N = 16,780), we found that low self-control in childhood was associated with the emergence and persistence of unemployment across four decades. On average, a 1-SD increase in self-control was associated with a reduction in the probability of unemployment of 1.4 percentage points after adjustment for intelligence, social class, and gender.”

Enlisting in the Military: The Influential Role of Genetic Factors“Given that enlistment in the U.S. military is completely voluntary, there has been a great deal of interest in identifying the various factors that might explain why some people join the military, whereas others do not. The current study expanded on this line of literature by estimating the extent to which genetic and environmental factors explained variance in the liability for lifetime participation in the military. Analysis of twin pairs drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health) revealed that 82% of the variance was the result of genetic factors, 18% of the variance was the result of nonshared environmental factors, and none of the variance was accounted for by shared environmental factors.” – from brian boutwell et al.

Risk of Suicide Among US Military Service Members Following Operation Enduring Freedom or Operation Iraqi Freedom Deployment and Separation From the US Military“Findings do not support an association between deployment and suicide mortality in this cohort. Early military separation (<4 years) and discharge that is not honorable were suicide risk factors.” – h/t michael story!

Verbal ability as a predictor of political preferences in the United States, 1974–2012“[H]igher vocabulary scores are associated with a greater likelihood that people place themselves on the ideological and political spectrum and that they vote in presidential elections, but have only small relationships with liberal-versus-conservative self-identification.”

Do our genes tell us how to vote? Study of twins says they might

On the Malleability and Plasticity of the History of the Blank Slate and 21st Century Moral Philosophy Advances Boldly into the 19th Century – from helian.

More on the younger Franz Boas – from peter frost.

Surnames and Y-Chromosomal Markers Reveal Low Relationships in Southern Spain – ruh roh.

New study finds genetic predisposition for noise-induced hearing loss

New function of obesity gene revealed

The placebome: Where genetics and the placebo effect meet

Chimps That Hunt Offer a New View on Evolution“[A] 10-year study of chimpanzees in Senegal shows females playing an unexpectedly big role in hunting and males, surprisingly, letting smaller and weaker hunters keep their prey. The results do not overturn the idea of dominant male hunters, said Jill D. Pruetz of Iowa State University, who led the study. But they may offer a new frame of reference on hunting, tools and human evolution. ‘We need to broaden our perspective,’ she said.”

Upper Palaeolithic ritualistic cannibalism at Gough’s Cave (Somerset, UK): The human remains from head to toe“Our present analysis of the postcrania has identified a far greater degree of human modification than recorded in earlier studies. We identify extensive evidence for defleshing, disarticulation, chewing, crushing of spongy bone, and the cracking of bones to extract marrow. The presence of human tooth marks on many of the postcranial bones provides incontrovertible evidence for cannibalism.”

Yes, You Can Catch Insanity“A controversial disease revives the debate about the immune system and mental illness.” – pediatric autoimmune neuropsychiatric disorders or “PANDAS”.

Hatfield and McCoy Feud — The Real Thing

Colors help set body’s internal clock“[Mice] use light’s changing color to set their own clocks, a finding that researchers expect will hold for humans, too.”

The Myth of the Angry Atheist“[T]hese results support the idea that people believe atheists are angry individuals, but they do not appear to be angrier than other individuals in reality.”

Flowers Are “Darker” at Lower Latitudes“UV radiation may explain why plants and animals closer to the equator come in darker varieties.”

The Disease That Turned Us Into Genetic-Information Junkies – brief history on tay–sachs disease research.

Antibiotic Resistant Bacteria Could Predate Antibiotics“A South American tribe, called the Yanomami, which was isolated for about 11,000 years prior to 2009, have gut bacteria that carry antibiotic resistance genes, according to new research. The Yanomami’s microbiome is far more diverse than that of Europeans or North Americans, but it also contains antibiotic resistant genes, despite never having had antibiotics. The findings suggest antibiotic resistance predates antibiotics, although it is possible the Yanomami ingested naturally occurring antibiotics in soil at some point.” – see also: The microbiome of uncontacted Amerindians.

Rotherham Worker ‘Told To Give Girls To Abusers’“The ex-protection worker says she repeatedly raised concerns about men taking girls away but her boss told her to ‘let them go’.” – also: State wards being groomed for prostitution by paedophile gangs“Organised gangs of paedophiles are grooming state wards as young as 12 for prostitution. Veteran child protection workers have told the Herald Sun they are powerless to protect the children in their care and that the sexual exploitation of state wards is ‘endemic’…. Victoria Police has set up a taskforce to investigate a gang of Afghani men in Dandenong suspected of preying on teens in care.” – australia now. =/

bonus: Jurassic Park in real life: The race to modify the DNA of endangered animals and resurrect extinct ones“Professor Church has applied a sophisticated and revolutionary ‘gene editing’ technique known as Crispr and has managed to get it working in elephant cells to carry out 14 precise changes to its genome. ‘We are now working on in vitro organogenesis [organ formation] and embryogenesis [embryo formation],’ he told The Independent in an email.”

bonus bonus: Genome Digest – findings from genomes of mountain gorilla, pseudomonas aeruginosa, canary, bird flu strain, and leprosy bacterium.

bonus bonus bonus: Through This Chemical Loop, Dogs Win Our Hearts

(note: comments do not require an email. woof?)

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The genetics of Mexico recapitulates Native American substructure and affects biomedical traits“We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.” – see also: People from Mexico show stunning amount of genetic diversity“When the team analyzed the genomes of 511 indigenous individuals from all over Mexico, they found a striking amount of genetic diversity. The most divergent indigenous groups in Mexico are as different from each other as Europeans are from East Asians, they report online today in Science. This diversity maps onto the geography of Mexico itself. The farther away ethnic groups live from each other, the more different their genomes turn out to be…. But most people in Mexico or of Mexican descent these days are not indigenous but rather mestizo, meaning they have a mixture of indigenous, European, and African ancestry. Do their genomes also vary by what region of Mexico they come from, or has all that local variation been smoothed out by centuries of different groups meeting, mixing, and having babies? To answer that question, the team collaborated with Mexico’s National Institute of Genomic Medicine, which has been collecting genetic data from mestizos for many years. Somewhat surprisingly, they found that mestizos in a given part of Mexico tended to have the same ‘rare’ genetic variants as their indigenous neighbors. The mestizo genomes ‘track so well with the indigenous groups that we could use the genetic diversity in mestizos to make inferences about [their native] ancestors,’ Pasaniuc says.”

Neanderthal-Human Skulls Shed Light on Evolution“Skulls found in a Spanish cave exhibit both Neanderthal and primitive human features, according to a new study published in the journal Science. The discovery provides clues about when the common ancestor of modern humans and Neanderthals lived, what happened after the two groups diverged, and how the two became so different over a relatively short period of time. There is consensus about the ending of the story: Modern humans and Neanderthals interbred, and Neanderthal DNA is still present in people of European and Asian ancestry. But the thousands of years before they connected, however, have been a mystery.” – see also: Palaeontology: How Neanderthals evolved“A study reveals that not all distinguishing features of hominid skulls have evolved at the same pace.”

Oldest human faeces show Neanderthals ate vegetables – eat your veggies!

Searching for Answers in Very Old DNA – interview with svante paabo.

Island-hopping odyssey brought civilisation to Europe“The farmers who brought advanced civilisation to Europe got there by sailing between the many islands strewn across the Aegean Sea between Greece and Turkey, according to a new genetic analysis. The first modern humans in Europe were hunter-gatherers who arrived around 40,000 years ago. But around 9000 years ago the first farmers arrived. They spread rapidly, dominating the continent by 7500 years ago, and pushing the hunter-gatherers into decline. The farmers originated in the Fertile Crescent in the Middle East, where farming arose, but until now no one knew which route they took to get to Europe.” – see also Publication Delays from greg cochran.

The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia“Peninsular Malaysia has greater genetic diversity corresponding to its role as a contact zone of both early and recent human migrations in Asia. However, each single Orang Asli (indigenous) group was less diverse with a smaller effective population size (Ne) than a European or an East Asian population, indicating a substantial isolation of some duration for these groups. All four MEGs were genetically more similar to Asian populations than to other continental groups, and the divergence time between MEGs and East Asian populations (12,000—6,000 years ago) was also much shorter than that between East Asians and Europeans. Thus, Malaysian Orang Asli groups, despite their significantly different features, may share a common origin with the other Asian groups. Nevertheless, we identified traces of recent gene flow from non-Asians to MEGs. Finally, natural selection signatures were detected in a batch of genes associated with immune response, human height, skin pigmentation, hair and facial morphology and blood pressure in MEGs. Notable examples include SYN3 which is associated with human height in all Orang Asli groups, a height-related gene (PNPT1) and two blood pressure-related genes (CDH13 and PAX5) in Negritos. We conclude that a long isolation period, subsequent gene flow and local adaptations have jointly shaped the genetic architectures of MEGs, and this study provides insight into the peopling and human migration history in Southeast Asia.”

Investigating brain connectivity heritability in a twin study using diffusion imaging data – h/t jayman! who tweeted: “Surprise, surprise: diffusion imaging twin study (N = 328) finds patterns of brain connectivity are heritable.”

The stability of self-control across childhood“Results indicate that variation [76%] in self-control is predominantly genetic.”

Race a factor in mortality in heart attack patients on anti-clotting drug“The first genetic variations linked to race have been identified that begin to explain a higher risk of death among some African American and Caucasian patients taking the anti-clotting drug clopidogrel after a heart attack. In particular, the team found that two DNA variants common in African Americans were associated with an increased risk of both bleeding and death. In Caucasians, a different variant was linked to additional heart attacks and a higher risk of death.” – h/t hbd bibliography!

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

GWAS-based pathway analysis differentiates between fluid and crystallized intelligence – h/t stuart ritchie! who tweeted: “Distinction between fluid and crystallised IQ at the genetic level.”

A hair-color allele of Neanderthal origin?“60-70% of Taiwanese aborigines have a loss-of-function allele at the main hair color gene, MC1R, yet their hair is as black as humans with the original ‘African’ allele. This seems to be a general pattern in Asians. They have fewer MC1R alleles than do Europeans, and the ones they have produce the same hair color.” – from peter frost.

Physical attractiveness as a phenotypic marker of health: an assessment using a nationally representative sample of American adults“[T]he more attractive a respondent was rated, the less likely he or she was to report being diagnosed with a wide range of chronic diseases and neuropsychological disorders. Importantly, this finding was observed for both sexes. These analyses provide further support for physical attractiveness as a phenotypic marker of health.”

Mellow, Paranoid, Happy, or Mean: Why do people respond so differently to the same drugs?“Although the research hasn’t settled on simple explanations, it’s clear that some combination of personality traits, genetics, and experience affects how people respond to intoxicants.”

How universal is empathy?“Pro-social behavior seems to be a human universal, but is the same true for full empathy?” – from peter frost.

Woodley launches his Victorian defence“The Woodley gang argue that, once they have done a complete re-analysis to respond to the points raised against their original ‘Victorians’ paper, their new results ‘reveal a seemingly robust secular trend towards slowing reaction time in these two countries, which translates into a potential dysgenics rate of −1.21 IQ points per decade, or −13.9 points in total between 1889 and 2004. We conclude by arguing that the best way forward is to test novel predictions stemming from our finding relating to molecular genetics, neurophysiology and alternative cognitive indicators, thus shifting the research focus away from the purely methodological level towards the broader nomological level. We thank our critics for helping us to arrive at a much more precise estimate of the decline in general intelligence.'” – @dr. james thompson’s blog.

HVGIQ: Cambodia and HVGIQ: Turks and Caicos Islands and HVGIQ: Vietnam – from jason malloy @human varieties.

U.S. Ethnic/Race Differences in Aptitude by Generation: An Exploratory Meta-analysis – from chuck @human varieties.

Ability, Effort, and Academic Achievement among Asian Americans – from steve hsu.

andrew “the goth” sabisky on the pisa tests/scores and their implications for education.

The Flynn effect and “real intelligence”(tm) and Why a mental age of eleven and an IQ of 70 are distinct – from elijah.

Embryo selection for cognitive enhancement: curiosity or game-changer?

Power to edit who you are – on CRISPR.

Reading to Newborns Is Probably Useless – from razib.

For One Baby, Life Begins with Genome Revealed“How a California father made an end run around medicine to decode his son’s DNA.” – on razib’s boy! (^_^)

Criminal offending as part of an alternative reproductive strategy: Investigating evolutionary hypotheses using Swedish total population data“Convicted criminal offenders had more children than individuals never convicted of a criminal offense. Criminal offenders also had more reproductive partners, were less often married, more likely to get remarried if ever married, and had more often contracted a sexually transmitted disease than non-offenders. Importantly, the increased reproductive success of criminals was explained by a fertility increase from having children with several different partners. We conclude that criminality appears to be adaptive in a contemporary industrialized country, and that this association can be explained by antisocial behavior being part of an adaptive alternative reproductive strategy.” – h/t mary lou cowan! – chicks dig jerks. – see also You dropped your glove, my liege from the awesome epigone.

Men Who Hate Women – from staffan.

Why women see differently from the way men see? A review of sex differences in cognition and sports – h/t keith laws!

For The First Time, Chimpanzees Are Making A Fashion Statement — Sticking Blades Of Grass In Their Ears“It’s a trend that’s taken a troop of chimpanzees by storm: a blade of grass dangling from an ear. The “grass-in-ear behavior,” as scientists have termed it, seems to be one of the first times that chimpanzees have created a tradition with no discernible purpose — a primate fashion statement, in other words…. There’s no genetic or ecological factors, the scientists believe, that would account for this behavior — only culture.” – but, but, but…where does chimp culture come from?

Faces of Old World monkeys evolved to prevent crossbreeding

No effects of androgen receptor gene CAG and GGC repeat polymorphisms on digit ratio (2D:4D): A comprehensive meta-analysis and critical evaluation of research“In contrast to a small-sample (N=50) initial report, widely cited affirmatively in the literature, meta-analysis of the entire retrievable evidence base did not support any associations between CAG variants and right-hand, left-hand, or right-minus-left-hand 2D:4D. Effects of GGC variants on digit ratios likewise were almost exactly null.” – h/t dr. zhana!

Parents of children with autism often have autistic traits – kid has all his ducks in a row! (~_^) – h/t jason moore!

Sensitive? Emotional? Empathetic? It could be in your genes“Do you jump to help the less fortunate or cry during sad movie scenes? If yes, you may be among the 20 percent of our population that is genetically pre-disposed to empathy, according to a study. The results provide further evidence that highly sensitive people are generally highly tuned into their environment, and provide evidence that especially high levels of awareness and emotional responsiveness are fundamental features of humans characterized as HSPs.” – h/t mr. robert ford!

Negotiating the gap: Four academics and the dilemma of human biodiversity – from peter frost.

Guns & Violence, Again – from jayman.

The Little Divergence“A ‘great divergence’ between the economies of Western Europe and East Asia had unambiguously occurred by 1800. However, there’s a growing body of opinion that this was preceded by a ‘little divergence’ which might have started as early as 1200. I argue that the pre-modern ‘little divergence’ was probably real, but that doesn’t mean it happened because of a modern growth process — a sustained rise in the production efficiency of the divergent economies. The ‘little divergence’ might be only a reflexion of those societies’ Malthusian balance of natality and mortality.” – from pseudo. – see also Addendum to The Little Divergence.

Searching for the “Free Will” Neuron“Gabriel Kreiman’s single-neuron measurements of unconscious decision-making may not topple Descartes, but they could someday point to ways we can learn to control ourselves.”

Denying the Tribe – from claire lehmann.

Mike Lotus Meeting with Emmanuel Todd in Paris, Discussing Todd’s Current Work and America 3.0“Todd spoke about the origins of the Absolute Nuclear Family, as contrasted with the Community Family which predominates in much of Eurasia. Todd said that his most recent book, ‘L’Origine des systemes familiaux’ he shows that the entire history of the world is understood backward. Specifically, the supposedly most backward places are the most advanced. He told me that he had made an absurd mistake in his early book The Explanation of Ideology: Family Structure and Social Systems. He said in Explanation that the distribution of family systems appeared to be random. But, he said, he should have realized that this could not be correct. He took out a pile of printer paper and with rapid strokes sketched an oval and filled in the center, noting that this was the community family area. It was a given that I understood that the oval was Eurasia. He then marked Xs around the periphery for England, Iceland, Finland, France, Japan, Korea, the Philippines all areas which were still individualistic in family structure. He said the book articulates the ‘Principle of Peripheral Conservation.’ The oldest known family structure is the Undifferentiated Nuclear Family (UNF). In England the UNF evolved into the ANF over many centuries. The Community Family forms took four to five thousand years to form and to reach their current state of development. In particular the subjugation of women took a very long time to complete in these systems. In other words, the societies which are currently considered the most modern have as a foundation an archaic family structure.” – h/t t.greer!

A Dozen Words for Misunderstood“Slaying, yet again, the idea that the languages we speak shape the thoughts we think.” – h/t steve stewart williams!

Understanding current causes of women’s underrepresentation in science“[D]ifferential gendered outcomes in the real world result from differences in resources attributable to choices, whether free or constrained, and that such choices could be influenced and better informed through education if resources were so directed. Thus, the ongoing focus on sex discrimination in reviewing, interviewing, and hiring represents costly, misplaced effort: Society is engaged in the present in solving problems of the past, rather than in addressing meaningful limitations deterring women’s participation in science, technology, engineering, and mathematics careers today.”

Breaking the Glass Ceiling? The Effect of Board Quotas on Female Labor Market Outcomes in Norway [pdf] – h/t ben southwood! who tweeted: “Norwegian gender quotas on boards had ‘very little discernible impact on women in business beyond its direct effect.'”

Archaeological cave dig unearths artefacts from 45,000 years ago“An archeological dig has revealed artefacts of early occupation so old they rival the dates of those found at sites of the earliest human settlement in Australia. The discovery of the artefacts of animal bone and charcoal at the Ganga Maya Cave (named by traditional owners meaning ‘house on the hill’) in the Pilbara region of Western Australia are the subject of a scientific paper not yet submitted to archaeological journals.”

Artificial cranial modification in Kow Swamp and Cohuna“This project provides added support for the argument that at least some Pleistocene Australian groups were practicing artificial cranial modification.” – h/t neuroskeptic!

Researchers discover 6,200-year-old schistosomiasis parasite egg“Researchers have discovered what they believe is the oldest ever schistosomiasis parasite egg in a 6,200-year-old grave by the Euphrates river in Syria, potentially providing the first evidence that Middle East agricultural irrigation systems – the artificial application of water to land or soil – may have contributed to the schistosomiasis burden.” – d*mn agriculture! – h/t adam benton @evoanth!

Tablet about payment of donkey debt discovered in Kültepe believed to be oldest trade document – h/t frau katze!

bonus: Assessment of Genetic Variability of Fish Personality Traits using Rainbow Trout Isogenic Lines“The study of inter-individual variability of personality in fish is a growing field of interest but the genetic basis of this complex trait is still poorly investigated due to the difficulty in controlling fish genetic origin and life history…. To this end, seven to ten rainbow trout isogenic lines were screened for their spatial exploratory behaviour, their flight response toward a stressor and their risk taking behaviour. Results showed that some lines seemed less sensitive to new events or environmental changes and could be defined as low responsive, while others were very sensitive and defined as high responsive.” – h/t justin tiehen!

bonus bonus: Meet one of your ancestors: a 505-million-year-old fish

bonus bonus bonus: H. pylori Bacteria Frantically Mutate to Establish Infection“A burst of rapid evolution allows Helicobacter pylori, the bacterium that causes ulcers in humans, to evade the immune system during the early, acute phase of infection. This finding complements earlier work that quantified how quickly H. pylori mutations accumulate during chronic infection. During the acute phase, mutational rates are 30 to 50 times greater than during the chronic phase.”

bonus bonus bonus bonus: An 81 million year herpes infection: First endogenous herpes virus found!

bonus bonus bonus bonus bonus: Scientific proof that dogs don’t like bananas

(note: comments do not require an email. social construct duck vs. social construct duck!)

Your Ancestors, Your Fate“The notion of genetic transmission of ‘social competence’ — some mysterious mix of drive and ability — may unsettle us. But studies of adoption, in some ways the most dramatic of social interventions, support this view. A number of studies of adopted children in the United States and Nordic countries show convincingly that their life chances are more strongly predicted from their biological parents than their adoptive families. In America, for example, the I.Q. of adopted children correlates with their adoptive parents’ when they are young, but the correlation is close to zero by adulthood. There is a low correlation between the incomes and educational attainment of adopted children and those of their adoptive parents. These studies, along with studies of correlations across various types of siblings (identical twins, fraternal twins, half siblings) suggest that genetics is the main carrier of social status.” – from gregory clark. see also The Son Also Rises: Surnames and the History of Social Mobility.

Reductionism! Determinism! Straw-man-ism!” The main problem, it seems to me, is a fundamental misunderstanding of what genetics as a science studies and how it relates to the function of complex systems. The following statements are not contradictory: 1. The function of a complex system emerges from the complex and dynamic interactions between all of the components of the system, in a context- and experience-dependent manner. 2. Variation in single components of the system (or in multiple components) can affect how it functions. Geneticists investigate the second question. Showing that variation in Gene X affects the behaviour or outcome of a system is not the same as saying that Gene X fully determines that behaviour or fully accounts for the entire system. Gene X is just a piece of DNA sitting in a cell somewhere – it doesn’t do anything by itself. But a *difference* in Gene X can account for a *difference* in how the system works. – from kevin mitchell.

The Problem with HBD, the Dark Enlightenment, Neoreaction, Alt-Rightism, and All That Jazz – READ THIS! – from jayman (and misdreavus).

There’s nothing wrong with looking for ‘gay genes’“The Left loves to tell the Right that it’s anti-science, pointing (not without reason) to the correlation between conservative beliefs and a failure to come to terms with the scientific facts of evolution and human-caused climate change. But there’s a subtler tendency on the Left; a fear of research into human nature, in case the findings are in some way politically uncomfortable.”

Evolution equally efficient in removing deleterious variants in Europeans and West Africans“…but apparently not in Denisovans who accumulated deleterious mutations at a higher rate than modern humans.” – @dienekes’.

Scientists unlock a ‘microbial Pompeii’“An international team of researchers have discovered a ‘microbial Pompeii’ preserved on the teeth of skeletons around 1,000 years old. The key to the discovery is the dental calculus (plaque) which preserves bacteria and microscopic particles of food on the surfaces of teeth, effectively creating a mineral tomb for microbiomes.”

The effect of paternal age on offspring intelligence and personality when controlling for paternal trait level [pdf] – “We examined the effect of father’s age at birth on offspring intelligence, head circumference and personality traits. Using the Minnesota Twin Family Study sample we tested paternal age effects while controlling for parents’ trait levels measured with the same precision as offspring’s. From evolutionary genetic considerations we predicted a negative effect of paternal age on offspring intelligence, but not on other traits. Controlling for parental intelligence (IQ) had the effect of turning an initially positive association non-significantly negative. We found paternal age effects on offspring IQ and Multidimensional Personality Questionnaire Absorption, but they were not robustly significant, nor replicable with additional covariates. No other noteworthy effects were found.” – from lars penke.

Reversed hierarchy in the brain for general and specific cognitive abilities: A morphometric analysis“Here, we analyze gray matter with three morphometric indices (volume, cortical surface area, and cortical thickness) at three levels of the intelligence hierarchy (tests, first-order factors, and a higher-order general factor, g)…. The key finding reveals substantial variability in gray matter correlates at the test level, which is substantially reduced for the first-order and the higher-order factors. This supports a reversed hierarchy in the brain with respect to cognitive abilities at different psychometric levels: the greater the generality, the smaller the number of relevant gray matter clusters accounting for individual differences in intelligent performance.” – h/t ben southwood!

A nice bunch of flowers“The general factor of intelligence is strongest at lower levels of intelligence. It may be a case of ‘All neurones to the pump’. When abilities are low, most problems are difficult. In such cases, all resources have to be thrown at the problem. When abilities are higher there is more spare capacity for differentiation of abilities. Brighter persons have a lower proportion of their abilities accounted for by a common factor, even though the have higher absolute abilities.” – from dr. james thompson.

GED scores by Ethnicity and Nation – from chuck @human varieties.

The Unfortunately Innate Nature of Intelligence“You cannot blame people for being what they were born, and you cannot expect them to do what they cannot.”

Psychologist on a mission to give every child a learning chip“Prof Robert Plomin wants educators to take notice of genes, and has a new big idea – personalised learning.”

Fruit-loving lemurs score higher on spatial memory tests“Food-finding tests in five lemur species show that fruit-eaters may have better spatial memory than lemurs with a more varied diet. The results support the idea that relying on foods that are seasonally available and far-flung gives a competitive edge to individuals with certain cognitive abilities — such as remembering where the goodies are.”

What Does Our DNA Say About How We Look?“A biologist aims to profile suspects from genetic material left at crime scenes.’ – h/t matthew wygant!

Four Lame Responses to Sam Harris’ Moral Landscape Challenge“Moral emotions, like every other evolved trait, exist because their presence increased the probability that the genes responsible for the existence of those traits would survive and reproduce. Moral emotions, and the associated illusions of the existence of Good and Evil as things in themselves, exist as subjective impressions in the minds of individuals.” – from helian.

Free will beliefs and motivation to punish“In a paper forthcoming in the Journal of Personality and Social Psychology, Cory J. Clark and co-authors provide evidence that widespread belief in the existence of free will is bolstered by a fundamental desire to punish wrongdoers…. As Clark et al. put it, ‘There seems little doubt that the subjective experience of choosing and acting supports people’s belief in free will, but our findings suggest another powerful motivating factor: the human impulse to blame and punish. People believe in free will – at least in part – because they wish to affirm that people who do immoral things could have and should have acted differently’.”

A small contribution to the free-will thingy – from elijah.

Is there a ‘dark intelligence’? Emotional intelligence is used by dark personalities to emotionally manipulate others“Narcissism and psychopathy increased link between emotional intelligence facets and emotional manipulation.” – h/t claire lehmann!

Theory of mind: did evolution fool us?“Although sophisticated ToM is believed to have high adaptive fitness, broad experimental evidence from behavioural economics, experimental psychology and linguistics point towards limited recursivity in representing other’s beliefs.” – h/t neuroskeptic!

Creativity and personality in classical, jazz and folk musicians“[J]azz musicians are more frequently engaged in extracurricular musical activities, and also complete a higher number of creative musical achievements. Additionally, jazz musicians show higher ideational creativity as measured by divergent thinking tasks, and tend to be more open to new experiences than classical musicians. This study provides first empirical evidence that jazz musicians show particularly high creativity with respect to domain-specific musical accomplishments but also in terms of domain-general indicators of divergent thinking ability that may be relevant for musical improvisation.” – h/t mary louise cowan!

Migration and interaction in a contact zone: mtDNA variation among Bantu-speakers in southern Africa“In this study, we analyze complete mtDNA genome sequences from over 900 Bantu-speaking individuals from Angola, Zambia, Namibia, and Botswana to investigate the demographic processes at play during the last stages of the Bantu expansion. Our results show that most of these Bantu-speaking populations are genetically very homogenous, with no genetic division between speakers of Eastern and Western Bantu languages. Most of the mtDNA diversity in our dataset is due to different degrees of admixture with autochthonous populations.”

Silver Blaze“[I]n most parts of Europe, it looks as if modern populations inherited the three EEF/WHG/ANE groups (Levantine farmers, West Hunters and Sibermen) via only two proximate ancestral populations. Europe at the time was almost entirely occupied by Sardinian-like farmers – then another population moved in, one that had about 3 times as much West Hunter as Sibermen.” – from greg cochran.

Replacement or continuity?“Ancient DNA seems to promise a clearer picture because the only source of uncertainty is the age of the skeletal material. Unfortunately, this new method is more sensitive to uncertainty from another source: natural selection. Late hunter-gatherers and early farmers had to adapt to different environments. There certainly was a genetic divide between the two, but did it result from differences in origin or from differences in natural selection?” – from peter frost.

Dystopian diversity – from the awesome epigone.

“I regret studying social anthropology” – me, too. *sigh* – see also the original post.

The parasite that escaped out of Africa: Tracing origins of malaria parasite“An international team has traced the origin of the second-worst malaria parasite of humans to Africa. The closest genetic relatives of human *Plasmodium vivax* were found only in Asian macaques, leading researchers to believe that *P. vivax* originated in Asia. This study overturns that, finding that wild-living apes in central Africa are widely infected with parasites that, genetically, are nearly identical to human *P. vivax*.” – h/t hbd bibliography!

Are Rich People Really That Selfish? – New Queendom.com Study Looks At Impact of Socio-Economic Status on Altruistic Tendencies“‘Our personality impacts every aspect of our life – the choices we make, the people we surround ourselves with, the career we pursue, the way we respond to life experiences, the way we manage our finances, and whether or not we share our good fortune,’ explains Dr. Jerabek, president of the company…. [H]ow individuals conduct themselves when they have money has everything to do with who they are as a person. Money doesn’t make a person more or less selfish. If you are a genuinely kind and giving person, you’ll continue to be that way no matter how many zeros are on your paycheck.'”

Babies born in England and Wales to non-UK born mothers infographic“Total Fertility Rate in England/Wales by where mother born: 4.3 Afghanistan, 3.8 Pakistan, 3.3 Nigeria, 2.4 India, 1.8 UK.”

The Tale of a CRISPR Clone – from razib.

Graft Probe in Scientific Community Widens in Southern China“A corruption probe has so far snared more than 50 scientists and research administrators in Guangdong, one of China’s wealthiest provinces.”

Quick Winter Olympics Digit Ratio Note – from sisyphean the mad contrarian.

Scientist proposes revolutionary naming system for all life on Earth“…a naming convention based on genome sequencing to enhance the way organisms are classified.” – h/t super mario!

Burials uncovered in Ireland reflect fusion of Paganism and Christianity“Excavations at Caherconnell in County Clare, Ireland, have uncovered ancient burials that reflect a fusion of Pagan practices with Christianity. Although it was initially believed that Christianity was well established in Ireland by the 5th Century, the latest finding reveals that Celtic Paganism was not quick to die out.” – h/t derek hopper!

The Society of Mutual Autopsy“The Society of Mutual Autopsy was an organisation formed in the late 1800s to advance neuroscience by examining dead members’ brains and to promote atheism by breaking sacred taboos.”

Heavy metal bands per 100,000 people – global map.

A Campus More Colorful Than Reality: Beware That College Brochure – h/t conrad hackett! who tweeted: “The whiter the college, the more diversity depicted in the brochures.”

bonus: Confirmed: Oldest Fragment of Early Earth is 4.4 Billion Years Old

bonus bonus: Hubble Finds Possible Oldest Object Ever Seen“The Hubble Telescope’s new set of Frontier Fields images includes a galaxy some 13-billion light-years away, which makes it a candidate for the most distant object ever seen.”

bonus bonus bonus: Rust Cohle, Guidance Counselor – heh. (~_^)

(note: comments do not require an email. rust cohle for president!)

oops! it happened again. =/

Deletion of Any Single Gene Provokes Mutations Elsewhere in the Genome“Johns Hopkins researchers report that the deletion of any single gene in yeast cells puts pressure on the organism’s genome to compensate, leading to a mutation in another gene…. ‘The deletion of any given gene usually results in one, or sometimes two, specific genes being “warped” in response….'”

Self-heal like Wolverine? Gene discovery might hold clues“In a discovery by a Harvard researcher, a reactivated gene found in embryos helps mice regrow clipped parts of their ears and toes. Could the ‘fountain of youth’ gene hold promise for humans too?” – i want one! – h/t mike anissimov!

Gene Variants Up CKD [chronic kidney disease] Risk in Blacks“A high-risk genetic variant conferred a significantly increased risk of progressive kidney disease in African Americans, at least partly explaining a racial disparity in end-stage renal disease (ESRD), investigators reported here. Analysis of black and white patients in another trial — half with diabetes — showed kidney function declined almost three times as fast in blacks with the high-risk APOL1 profile as compared with whites….”

Genetic clue to high heart risk of black Americans“The gene that produces the protein [PC-TP which activates a clotting factor called PAR4] is four times more active in the platelets of black Americans than it is in white Americans.” – h/t hbd bibliography!

Europeans and South Asians share by descent SLC24A5 light skin allele“‘We date the coalescence of the light skin associated allele at 22–28 KYA. Both our sequence and genome-wide genotype data confirm that this gene has been a target for positive selection among Europeans. However, the latter also shows additional evidence of selection in populations of the Middle East, Central Asia, Pakistan and North India but not in South India.'” – @dienekes’.

The ancestors with no descendants“On the eve of the last ice age, Siberia was home to a people who were related to modern Europeans and Amerindians but not to modern native Siberians. So concludes an analysis of DNA from the remains of a boy who lived 24,000 years ago at Mal’ta near Lake Baikal, Siberia…. [T]he Mal’ta people probably looked very much like native Indians with a more European skull shape, perhaps like the Ainu of northern Japan or the Kennewick humans of North America.”

Political colour is half genetic“New study provides definitive evidence that heritability plays a significant role in the formation of political ideology, regardless of how ideology is measured, the time period or population sampled.” – @ScienceNordic.com – the photo caption is pretty funny/telling: “Imagine if scientists could identify the ‘liberal’ genes and genetically modify babies so that they all voted liberal when they grow up? Brave new world?” (and the first comment is priceless!) – h/t ray sawhill!

It’s not just conservatives that support discrimination against their ideological foes“‘Discrimination by liberals has received scant attention in the literature, despite this being a prevalent concern in conservative rhetoric. By only examining conservative biases, social scientists fail to fully explore political intolerance in America. This research helps fill that gap….’ When opposing groups were seen as violating core values, liberals were just as likely to support discrimination against same-sex marriage opponents, religious fundamentalists, Tea Party protestors, and prolife people as were conservatives against feminists, atheists, leftist protestors, and prochoice people.”

Politics Has an Odor“[C]onservatives are significantly more likely than liberals to detect [bitter tasting] PTC [phenylthiocarbamide].” – h/t jayman!

Study: Your brain sees things you don’t“Our brains perceive objects in everyday life of which we may never be aware, a study finds, challenging currently accepted models about how the brain processes visual information.”

New evidence on the biological basis of highly impulsive and aggressive behaviors“Physical and chemical changes in the brain during development can potentially play a role in some delinquent and deviant behaviors.”

Root of maths genius sought“Entrepreneur’s ‘Project Einstein’ taps 400 top academics for their DNA.”

Has a 15-year-old explained the Flynn Effect? – on elijah amstrong and michael woodley’s newly published paper! – from steve sailer.

Is young Woodley down for the count? – never! (^_^) – from dr. james thompson.

Religions of the American Nations“[T]hese differences [regional cultural and political divisions in america] stem from the *genetic* differences in the descendants of these initial settlers (suffused with the genes of subsequent immigrants, particularly in the old North).” – from jayman.

In Hookups, Inequality Still Reigns“[A] study of 24,000 students at 21 colleges over five years found that about 40 percent of women had an orgasm during their last hookup involving intercourse, while 80 percent of men did.” – h/t john durant!

The Co-Villains Behind Obesity’s Rise“Not everyone, however, has the same gut bacteria. And, interestingly, the composition of this bacteria correlates with obesity…. [T]he bacteria study found that the ‘obese gut bacteria’ had an impact only when the mice were fed diets heavy in saturated fats.” – h/t jayman!

Rich Chinese Couples Turning To American Surrogates For Easier Immigration And ‘Designer Babies’“Another factor that has some Chinese couples choosing American surrogates is a desire for ‘designer babies.’ While most couples still use their own eggs and sperm, making the child biologically theirs, Reuters reports that more and more people are open to egg donation, to get what some clients believe are smarter and better-looking children. ‘Lots of clients that are Chinese do use tall, blond donors,’ Jennifer Garcia, who works at Extraordinary Conception in California, where 40 percent of clients are Chinese, said in the report.” – h/t mark krikorian!

CRISPR gene therapy: Scientists call for more public debate around breakthrough technique“‘I’m sure there will be some concern about the possibility that the technology could be used for “enhancement” rather than repair, veering from medicine towards eugenics,’ [professor wells] warned.” – oh noes! not “enhancement”! *swoon!* h/t anatoly!

Should state education be abolished?“New York City adopting Finland’s education system is not going to make New York like Finland…. In the game of life the dice are loaded and trying to make teachers responsible for making life fair is deluded and unfair to them….” – from ed west.

Shaker Heights – from greg cochran.

John Derbyshire’s Modest Proposal On Politics and Intelligence“And the too-dumb-to-vote segment is only a part of the problem we conservatives have with universal suffrage. Here’s another part: too *smart* to vote…. At the very highest levels of intelligence, the correlation between IQ and sensible political opinions may actually be *inverse*: the more brilliant you are, the dumber your politics. Albert Einstein thought well of Stalin; Hitlerism got its first mass following in the highly-selective German universities.”

Amid austerity and debt, Denmark remains happiest nation“The second pillar of happiness is a high level of trust between people, even for a stranger on the street….” – crazy danes! (~_^)

Introducing the Mongol Project“‘I will now tell you all about the Tartars and how they acquired their empire and spread throughout the world.'” – excellent! – from t.greer.

Early uses of chili peppers in Mexico“Chili peppers may have been used to make spicy beverages thousands of years ago in Mexico….”

Case of Insect Interruptus Yields a Rare Fossil Find“[T]he oldest fossil of two insects copulating.” – 165 million years old!

This Is How Much Money You’ll Make Based on Your Personality – d*mn. =/

bonus: Another Word for “Holocaust”“[O]ne would have to be smoking banana peels dipped in formaldehyde and sprinkled with PCP to assert that both events [the holocaust and the holodomor] receive a similar amount of attention in Western media and academia.” – from jim goad. of course.

bonus bonus: Swedish cinemas launch feminist movie rating – hahahahahaha!!! heh. wait. (*hbd chick wipes tears from eyes*) heh. – “To get an ‘A’ rating, a movie must pass the so-called Bechdel test, which means it must have at least two named female characters who talk to each other about something other than a man….” – hahahahahaha!! – “The entire ‘Lord of the Rings’ trilogy, all ‘Star Wars’ movies, ‘The Social Network,’ ‘Pulp Fiction’ and all but one of the ‘Harry Potter’ movies fail this test,” – so, except for The Social Network, all of my faves. this is going to be a REALLY handy movie rating system. whatever movies they FAIL, i will go see! (^_^)

bonus bonus bonus: Strange Doings on the Sun“Sunspots, Which Can Harm Electronics on Earth, Are Half the Number Expected” – ruh roh.

bonus bonus bonus bonus: Large magma reservoir gets bigger – ruh roh.

bonus bonus bonus bonus bonus: This amazing fruit fly evolved to have pictures of ants on its wings – srsly! – h/t jayman!

(note: comments do not require an email. rupee – first dog to climb mt. everest. woof!)