a linkfest! (^_^) ’cause i hate linkfasts, too. (*^_^*)

Whole genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection“African Pygmies practicing a mobile hunter-gatherer lifestyle are phenotypically and genetically diverged from other anatomically modern humans, and they likely experienced strong selective pressures due to their unique lifestyle in the Central African rainforest…. Our two best-fit models both suggest ancient divergence between the ancestors of the farmers and Pygmies, 90,000 or 150,000 years ago. We also find that bi-directional asymmetric gene-flow is statistically better supported than a single pulse of unidirectional gene flow from farmers to Pygmies, as previously suggested…. We found that genes and gene sets involved in muscle development, bone synthesis, immunity, reproduction, cell signaling and development, and energy metabolism are likely to be targets of positive natural selection in Western African Pygmies or their recent ancestors.”

Directional dominance on stature and cognition in diverse human populations“[I]ncreased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5, 6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.” – see also Not tonight, cousin from dr. james thompson. and see also Inbreeding from greg cochran. and see also Directional dominance on stature and cognition from steve hsu.

Genes Unite Executive Functions in Childhood [pdf] – h/t brian boutwell! who tweeted: “Shared genes explain all of the covariance in exec functioning items. No parenting effects to be found.”

200 Blog Posts – Everything You Need to Know (To Start) and The Rise of Universalism and Demography is Destiny, American Nations Edition and National Prosperity – jayman’s been on a roll lately! (^_^) each of these warrants your close attention!

Heritability and the evolution of cognitive traits

CNVs in neuropsychiatric disorders“Over the last few years at least 11 copy number variations (CNVs) have been shown convincingly to increase risk to developing schizophrenia: deletions at 1q21.1, NRXN1, 3q29, 15q11.2, 15q13.3 and 22q11.2, and duplications at 1q21.1, 7q11.23, 15q11.2-q13.1, 16p13.1 and proximal 16p11.2. They are very rare, found cumulatively in 2.4% of patients with schizophrenia and in only 0.5% of controls. They all increase risk for other neurodevelopmental disorders, such as developmental delay and autism spectrum disorders, where they are found at higher rates (3.3%). Their involvement in bipolar affective disorder is much less prominent. All of them affect multiple genes (apart from NRXN1) and cause substantial increases in risk to develop schizophrenia (odds ratios of 2 to over 50). Their penetrance for any neurodevelopmental disorder is high, from ∼10% to nearly 100%. Carriers of these CNVs display cognitive deficits, even when free of neuropsychiatric disorders.”

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations [pdf] – h/t dr. xaverius!

County level homicide rates by race/ethnicity of victim and On the effects of wealth on the B-W gaps, a response to questions posed by a commenter @random critical analysis.

the much discussed post The IQ Gap Is No Longer a Black and White Issue – from chanda chisala. see also Chanda Chisala: An African Hereditarian?“If evolution applies to all of us, that includes Africans. It is perfectly possible that some African sub-groups are brighter than others. Any geographic group which takes care to encourage bright persons to marry one another could see positive effects after 20-30 generations of consistently strong selection, if those brighter parents have more surviving offspring, which is likely.” – from dr. james thompson. and see also The Jews of West Africa? from peter frost. and see also my post: there’s more to human biodiversity than just racial differences.

The Water-Crossers – from greg cochran.

Ancestry Matters: Patrilineage Growth and Extinction – h/t ben southwood! who tweeted: “Higher status Chinese patrilineages in the 18th and 19th centuries had more ancestors for hundreds of years after.”

The puzzle of European hair, eye, and skin color – from peter frost.

The people who need very little sleep

How evolutionary psychology may explain the difference between male and female serial killers“[R]esearch has shown that male serial killers tend to stalk and kill strangers. But FSKs tend to kill people they know. It seems, then, that MSKs are hunters and FSKs are gatherers.”

Is the Romantic–Sexual Kiss a Near Human Universal – apparently not! – “The romantic–sexual kiss was present in a minority of cultures sampled (46%). Moreover, there is a strong correlation between the frequency of the romantic–sexual kiss and a society’s relative social complexity: the more socially complex the culture, the higher frequency of romantic–sexual kissing.”

Men are both dumber and smarter than women – just an ok article, but interesting to see this out there *at all*.

Historical Artifacts of the Blank Slate – from helian.

On a Fast Track – Can rapid genome sequencing at birth help save lives?

Genomics Industry Generating Huge Amounts Of Data Due To DNA Sequencing – yay!

Ageing rates vary widely, says study“A study of people born within a year of each other has uncovered a huge gulf in the speed at which their bodies age…. [S]ome people had almost stopped ageing during the period of the study, while others were gaining nearly three years of biological age for every twelve months that passed.” – original research article: Quantification of biological aging in young adults.

Reacting to Spree Killings, Progressively – @thosewhocansee.

for you brits: Is that stranger opposite you a distant cousin?

bonus: Pluto’s discoverer’s ashes will be the first human remains to leave the solar system — glued to the side of a space probe – *sniff*

bonus bonus: r.i.p. conrad – *sniff*

bonus bonus bonus: tweet of the week! (~_^) >>

(note: comments do not require an email. r.i.p. conrad. *sniff*)

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