Archives for posts with tag: drd4

Finland & Japan – exceptions to “the rule”? – from jayman!

Genetic pacification in medieval Europe – from peter frost!

Scientists May Have Finally Unlocked Puzzle of Why People Are Gay – an epigenetic cause of gayness?

Restless Genes – drd4.

Reconstructed Face of Extinct “Hobbit” Species Is Startlingly Humanlike

Polymorphisms and Load – (more stuff i barely understand) from greg cochran!

Penn Study shows resistance to cocaine addiction may be passed down from father to son – in rats anyway.

Where to be born vs. where people are being born – from the awesome epigone!

The mu opioid receptor genotype may be a marker for those who drink for alcohol’s rewarding effects – OPRM1.

bonus: Lead poisoning in Samurai kids linked to mom’s makeup

bonus bonus: OU Study Suggests the Bacterial Ecology That Lives on Humans Has Changed Dramatically in the Last 100 Years

bonus bonus bonus: Microbiome: Cultural differences“Studies of gut bacteria are beginning to untangle how diet affects health in old age — but determining cause and effect is tricky.”

bonus bonus bonus bonus: Art of cheese-making is 7,500 years old

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today, some classics (and soon-to-be classics?):

Latitude, elevation and the tempo of molecular evolution in mammals“[B]ecause climatic variables change with latitude and elevation in a similar manner, our results suggest that climate has influenced the tempo of genetic change in mammals…. These findings provide new insights into microevolution that are likely to have important implications for understanding global patterns of biodiversity and diversification.”

An Asian perspective on early human dispersal from Africa“Asia might not have been the passive recipient of whatever migrated out of Africa but might have been a major donor to speciation events, as well as dispersals back into Africa. Such two-way traffic is well documented for other mammals in the Pliocene and Early Pleistocene, such as Equus and bovids, with more taxa migrating into than out of Africa. There is no reason why hominin migrations were always from Africa into Asia, and movements in the opposite direction might also have occurred, as has been suggested for the Olduvai OH9 (refs 13, 58) and Daka specimens. We should even allow for the possibility that H. ergaster originated in Asia and perhaps explain its lack of an obvious east African ancestry as the result of immigration rather than a short (and undocumented) process of anagenetic (in situ) evolution (Dennell and Roebroeks 2005:1100-1101).” – see also: Did Early Humans First Arise in Asia, Not Africa?

Recent acceleration of human adaptive evolution“It is sometimes claimed that the pace of human evolution should have slowed as cultural adaptation supplanted genetic adaptation…. Cultural changes have reduced mortality rates, but variance in reproduction has continued to fuel genetic change. In our view, the rapid cultural evolution during the Late Pleistocene created vastly more opportunities for further genetic change, not fewer, as new avenues emerged for communication, social interactions, and creativity.” – hawks, wang, cochran, harpending & moyzis.

Innate Social Aptitudes of Man: An Approach from Evolutionary Genetics [opens pdf] – w.d. hamilton.

How obedience of marriage rules may counteract genetic drift“Continuous unilateral or bilateral cross-cousin mating, reflecting the most common form of prescribed marriage, increases homozygosity but at the same time slows down considerably the loss of gene diversity due to genetic drift.”

It’s All Relative: Race as partly inbred extended family – from steve sailer.

Human genetic diversity: Lewontin’s fallacy [opens pdf] – “In popular articles that play down the genetical differences among human populations, it is often stated that about 85% of the total genetical variation is due to individual differences within populations and only 15% to differences between populations or ethnic groups. … This conclusion, due to R.C. Lewontin in 1972, is unwarranted because the argument ignores the fact that most of the information that distinguishes populations is hidden in the correlation structure of the data and not simply in the variation of the individual factors.”

Discerning the Ancestry of European Americans in Genetic Association Studies“Here we mine much larger datasets (more markers and more samples) to identify a panel of 300 highly ancestry-informative markers which accurately distinguish not just northwest and southeast European, but also Ashkenazi Jewish ancestry.”

Genes predict village of origin in rural Europe“After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89–100% of individuals.”

E Pluribus Unum: Diversity and Community in the Twenty-first Century [opens pdf] – “New evidence from the US suggests that in ethnically diverse neighbourhoods residents of all races tend to ‘hunker down’. Trust (even of one’s own race) is lower, altruism and community cooperation rarer, friends fewer.” – robert putnam.

The Misguided Advocates of Open Borders“Rising diversity within human societies tends to drive people apart, causing them to take sanctuary in individual pursuits and ethnic communities. The practical consequences are reduced public altruism or social capital, evident in falling volunteerism, government welfare for the aged and sick, public health care and a general loss of trust. Ethnic diversity is second only to lack of democracy in predicting civil war. Globally it correlates negatively with governmental efficiency and prosperity.” – frank salter.

Why g Matters: The Complexity of Everyday Life [opens pdf] – linda gottfredson.

State IQ estimates (2009) – from the awesome epigone.

Inbreeding depression and IQ in a study of 72 countries [opens pdf]. see also Consanguinity and national IQ scores.

American Murder Mystery“Why is crime rising in so many American cities? The answer implicates one of the most celebrated antipoverty programs of recent decades.” – h/t anonymous.

bonus: Ethnic differences: Variation in human testis Size – jared diamond.

bonus bonus: Late Middle Eocene primate from Myanmar and the initial anthropoid colonization of Africa

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How Much Hard Evidence Do You Need?“[T]hree dopamine genes … examined, the dopamine transporter gene (DAT1), the dopamine D2 receptor gene (DRD2), and the dopamine D4 receptor gene (DRD4), had small but reliable effects on educational attainment, such that those with a higher ‘dopamine index’ tended to attain less education…. But what’s much more interesting is that they found significant differences in the prevalence of the alleles of theses genes between the White and the Black subjects, with Blacks having tending to have higher dopamine indices.” – from jayman (at his new location!).

Earliest Americans Arrived in Waves, DNA Study Finds – via steve sailer.

Spearheads and DNA Point to a Second Founding Society in North America“Clovis people, long known for their graceful, fluted projectile points, were not alone in the New World.” – original research article. see also: Paisley Caves yield 13,000-year old Western Stemmed points, more human DNA.

New Au. sediba fossils discovered in rock“Bones to be unearthed ‘live’ online, in a laboratory studio in real time.”

Fascinatin’ rhythm“[A] Neanderthal-derived segment that overlaps CLOCK, a key gene in regulating circadian rhythms. That segment has a frequency of 85% in Europeans.” – from greg cochran.

Pathological Altruism – jared taylor reviews Pathological Altruism.

Bad News for Big Brains“Humans and other creatures with large brains relative to their body size tend to have smaller guts and possibly fewer offspring. Scientists have debated for decades whether the two phenomena are related. Now a team of researchers says that they are—and that big brains do indeed make us smart.”

IQ and fertility cross-nationally – bad news from the inductivist.

The IQ’s Of Russian Politicians – anatoly guesstimates.

Intro to kinship and inbreeding coefficients“Fair warning: this is the most mathematical post I have ever done. If you hate math or are not good at it, don’t bother reading this post.” – from secular blood. also: On inbreeding coefficients and On kinship coefficients.

Women’s body movements are a potential cue to ovulation – something in the way she moves….

Natural Alzheimer’s Protection“Researchers identify a gene variant that reduces risk of Alzheimer’s disease.”

Q: Why Do We Wear Pants? A: Horses

bonus: Fruitflies evolve number sense

bonus bonus: Falling Dominoes – in china.

bonus bonus bonus: Feeling Snappy? Measuring Personality in Hermit Crabs

bonus bonus bonus bonus: Papua New Guinea charges 29 alleged cannibals

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Genes May Play Role in Educational Achievement, Study Finds“Researchers have identified genetic markers that may influence whether a person finishes high school and goes on to college, according to a national longitudinal study of thousands of young Americans…. The three genes identified in the study – DAT1, DRD2 and DRD4 – have been linked to behaviors such as attention regulation, motivation, violence, cognitive skills and intelligence, according to the study.”

Racial bias colours visual perception“Prejudiced people slowest to recognize faces from other races.” – or maybe people who are slowest to recognize faces from other races are the most “prejudiced”?

Cross-national IQ, inequality, and homicide – from the inductivist.

Research shows endowment effect in chimpanzees can be turned on and off“‘These results strongly support the idea that the endowment effect reflects the deep influence of evolutionary processes – notably natural selection – on psychological predispositions that affect how brains ascribe value to objects.’”

A scientific study reveals that individuals cooperate according to their emotional state and their prior experiences“[P]eople do not act thinking in their own reward, as had been previously believed, but rather individuals are more influenced by their own mood at the time and by the number of individuals with whom they have cooperated before.”

Baby makers scorn porn? – from the awesome epigone.

Chronic pain is determined by emotions, scientists believe“The more emotionally the brain reacted to the initial injury, the more likely it was that pain will persist after the injury has healed, he said. Prof Apakarian added: ‘It may be that these sections of the brain are more excited to begin with in certain individuals, or there may be genetic and environmental influences that predispose these brain regions to interact at an excitable level.’”

‘Cat ladies’ more likely to commit suicide, scientists claim“Researchers found women infected with the Toxoplasma gondii (T. gondii) parasite, which is spread through contact with cat faeces or eating undercooked meat or unwashed vegetables, are at increased risk of attempting suicide.”

Autism, schizophrenia and bipolar disorder may share common underlying factors, study suggests“New research led by a medical geneticist at the University of North Carolina School of Medicine points to an increased risk of autism spectrum disorders (ASDs) among individuals whose parents or siblings have been diagnosed with schizophrenia or bipolar disorder.”

O Brother, Who Art Thou? – review of Born Together – Reared Apart: The Landmark Minnesota Twin Study.

23andMe Contributes to Genetic Discoveries Related to Breast Size and Breast Cancer“23andMe … has identified seven single-nucleotide polymorphisms (SNPs) significantly associated with breast size, including three SNPs also correlated with breast cancer in a genome-wide association study (GWAS) now published online in BMC Medical Genetics. These findings make the first concrete genetic link between breast size and breast cancer risks.” – they looked at data from women of european ancestry.

Researchers Find a Brain Center for Social Choices“Poker-playing subjects seen weighing whether to bluff.”

bonus: the higgs! (maybe/probably)

bonus bonus: The ‘appetite-suppressing’ effect of proteins explained

bonus bonus bonus: Plants that feed on animals underground discovered“Three species of carnivorous plant that feed on worms underground have been discovered in the Brazilian savannah.”

bonus bonus bonus bonus: Women ‘deliberately post ugly photos of friends online’ – heh.

bonus bonus bonus bonus bonus: Dogs May Mourn as Deeply as Humans Do – dogs are people, too.

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yes, astrology is bunk. but, like i was saying a couple of weeks ago (prompted by hail’s musings), there might be a little something to it all, i.e. that das folk happened to notice that people born during different times of the year were, on average, kinda different in their personalities.

here’s the sort of thing i’m thinking of — some research from a couple of years ago:

Season of Birth and Dopamine Receptor Gene Associations with Impulsivity, Sensation Seeking and Reproductive Behaviors

Season of birth (SOB) has been associated with many physiological and psychological traits including novelty seeking and sensation seeking. Similar traits have been associated with genetic polymorphisms in the dopamine system. SOB and dopamine receptor genetic polymorphisms may independently and interactively influence similar behaviors through their common effects on the dopaminergic system….

Winter-born males were more sensation seeking than non-winter born males. In factorial models including both genotype and season of birth as variables, two previously unobserved effects were discovered: (1) a SOB×DRD4 interaction effect on venturesomeness and (2) a DRD2×DRD4 interaction effect on sensation seeking.

“Conclusion

“These results are consistent with past findings that SOB is related to sensation seeking. Additionally, these results provide tentative support for the hypothesis that SOB modifies the behavioral expression of dopaminergic genetic polymorphism. These findings suggest that SOB should be included in future studies of risky behaviors and behavioral genetic studies of the dopamine system.”

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one of the questions always floating around in the hbd-o-sphere is why aren’t those really clever east asians more creative.

well, kiwiguy over @dennis’ commented the other day:

“Cochran & Harpending discuss a gene associated with ADD & impulsive behaviour in ‘The 10,000 Year Explosion‘:

“‘The polymorphism is found at varying but significant levels in many parts of the world, but is almost entirely absent from East Asia…

“‘The Japanese say that the nail that sticks out is hammered down, but in China it may have been pulled out and thrown away.

Selection for submission to authority sounds unnervingly like domestication…’ (page 112)”

(*hbdchick reaches for her copy of the book*)

yup. kiwiguy is right. says here right on page 112:

“We know of a gene that may play a part in this story: the 7R (for 7-repeat) allele of the DRD4 (dopamine receptor D4) gene. It is associated with Attention-Deficit/Hyperactivity Disorder (ADHD), a behavioral syndrome best characterized by actions that annoy elementary school teachers: restless-impulsive behavior, inattention, distractibility, and the like.

“The polymorphism is found at varying but significant levels in many parts of the world, but is almost totally absent from East Asia. Interestingly, alleles derived from the 7R allele are fairly common in China, even though the 7R alleles themselves are extremely rare there. It is possible that individuals bearing these alleles were selected against because of cultural patterns in China. The Japanese say that the nail that sticks out is hammered down, but in China it may have been pulled out and thrown away.”

now here’s an article that i happened to link to in this past sunday’s linkfest:

Creativity is an upside to ADHD

“Parents who believe that attention deficit hyperactivity disorder makes their kids more creative got a little more scientific support recently.

“A new study in the Journal of Personality and Individual Differences found adults with ADHD enjoyed more creative achievement than those who didn’t have the disorder.

“‘For the same reason that ADHD might create problems, like distraction, it can also allow an openness to new ideas,’ says Holly White, assistant professor of cognitive psychology at Eckerd College in St. Petersburg, Florida and co-author of the paper. ‘Not being completely focused on a task lets the mind make associations that might not have happened otherwise….’”

so, there you go! low frequencies of adhd genes = low creativity. solved that for ya. ENGLISH BLOKE solved that for ya first. (~_^) ur welcome!

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“Happiness ‘is about earning more than your friends’” – on the easterlin paradox.

“Why Surgeons Dread Redheads”

“Rich Women Prefer Attractive Older Men”“Greater income makes women prefer even older men, and men prefer even younger women.”

“Like to Sleep Around? Blame Your Genes” – drd4 (again).

“Mental function improves after certain kinds of socializing”“Talking with other people in a friendly way can make it easier to solve common problems.”

“Power and Corruption May Be Good for Society”

“Still growing up at 40: Throwing tantrums in middle age? That’s because your brain is learning to be adult”“It is also possible that the cut-off point [for when brain development stops] is different in cultures with very different lifestyles.”

“Neanderthals Fashioned Earliest Tool Made From Human Bone”

“Researchers find a ‘liberal gene’” – more from randall “parapundit” parker.

“W.D. Hamilton on Dysgenics, Eugenics, and Educational Romanticism” @vdare.com.

“The Other ‘G’ Spot” – (via diversityischaos) “[D]o people who score high on IQ tests use the frontal and parietal areas of their brains differently from people who score lower? The answer, discovered by other researchers, turns out to be yes.”

“Ich bin Mittel-Ostländer?” @evoandproud.

from inductivist: “Three dopaminergic genes predict grades in school”“I should note that the multivariate model includes race and gender, and the effect of race on grades remains when genes are entered into the equation. In fact, the impact of race is stronger than the three genes together.”

“Stories vs. Statistics”

“The tea party warns of a New Elite. They’re right.” – Charles Murray on the bobos in paradise.

“How taking the Pill can bring out a woman’s jealous and possessive side”

“Asian Neanderthals, Humans Mated” – in east asia.

“Stone Age DIY: How Neolithic man decorated his house with homemade paint”“It is the earliest ever example of man using paint to decorate their properties in Britain, if not in Europe.”

“Rising to the occasion”“Electoral victory brings a surprising consequence: the winners look at smut”

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